University of Connecticut · Microbiology & ImmunologyWang Inflammasome Lab
Penghua Wang · Storrs, Connecticut
Research Focus
Dr. Penghua Wang's lab focuses on understanding the role of non-canonical inflammasomes in the immune response, particularly during infections that can lead to severe illnesses like sepsis. By studying how specific proteins, such as UBXN1, regulate inflammation, the lab aims to uncover new pathways that could lead to better treatments for sepsis and related inflammatory diseases.
inflammasomessepsisnon-canonical signalingubiquitininflammation
Research Aims
5AIM 01Investigate the role of UBXN1 in non-canonical inflammasome signaling.
AIM 02Identify novel interactors of caspase-4 in the context of inflammation.
AIM 03Characterize the mechanisms of unanchored ubiquitin chains in immune response.
AIM 04Develop small molecule inhibitors targeting UBXN1 for sepsis treatment.
AIM 05Study the physiological functions of UBXN1 in animal models of sepsis.
Skills the Lab Values
cell culturein vivo animal modelsimmunoprecipitationbiochemical assaysmass spectrometryCRISPR/Cas9Western blottingmicroscopygenetic manipulation
Output against the department
Publications151top 43% of dept.209th of 486
this lab
most publishedleast published
Citations8.7ktop 41% of dept.201st of 486
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.