West Virginia University · PharmacologyMitochondrial Neuroprotection Lab
Jason D Huber · Morgantown, West Virginia
Research Focus
Dr. Jason D Huber's research focuses on understanding how mitochondrial dysfunction contributes to brain injury following an ischemic stroke. His team investigates a specific mitochondrial protein called mitoNEET and its role in protecting brain cells from damage caused by reduced blood flow and subsequent cell death. The lab aims to develop new therapeutic approaches that could enhance recovery after strokes, using a novel compound they've created to target this protein.
ischemic strokemitochondrial dysfunctionmitoNEETneuroprotectionferroptosisbrain injurydrug development
Research Aims
4AIM 01Investigate how mitoNEET modulation affects neuronal survival during ischemic injury.
AIM 02Determine the mechanism through which mitoNEET influences iron accumulation in the brain post-stroke.
AIM 03Assess the impact of NL-1 on the blood-brain barrier integrity after ischemic events.
AIM 04Evaluate the potential of NL-1 as a therapeutic intervention for ischemic stroke recovery.
Skills the Lab Values
cell culturein vitro modelingWestern blotimmunohistochemistryanimal models (rats, mice)pharmacological assaysflow cytometrymolecular biology techniquesdata analysis using statistical software
Output against the department
Publications112bottom 30% of dept.319th of 462
this lab
most publishedleast published
Citations6.3kbottom 45% of dept.255th of 462
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.