University of Minnesota-Twin Cities · BiologyThymic T Cell Tolerance Lab
Kristin A. Hogquist · Minneapolis, Minnesota
Research Focus
Dr. Kristin A. Hogquist's research lab at the University of Minnesota focuses on understanding how the thymus develops T cells that can tolerate self-antigens to prevent autoimmune diseases. The lab investigates how innate immune activation affects the selection processes of T cells in the thymus, particularly looking at the roles of cytokines like interferons. By studying the interactions between various immune cells, the lab aims to uncover mechanisms that could lead to better understanding and treatment of autoimmune conditions.
T cell tolerancethymic selectionautoimmunityinnate immune activationinterferonsantigen presenting cellsTreg cellshumoral immunityB cell activation
Research Aims
3AIM 01Test if thymic interferon provides T cell tolerance to self-antigens.
AIM 02Determine the effects of IFN deficiency on thymic selection processes.
AIM 03Investigate the role of interferon-licensed B cells in Treg cell selection.
Skills the Lab Values
T cell receptor repertoire sequencingcell culturemouse modelsflow cytometryimmune cell isolationgene expression analysisimmunofluorescence microscopycytokine profilingbiological assays
Output against the department
Publications288top 20% of dept.206th of 1,033
this lab
most publishedleast published
Citations27ktop 13% of dept.135th of 1,033
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.