University of Arizona · BiologyGranzier Lab
Henk L. Granzier · Tucson, Arizona
Research Focus
Dr. Henk Granzier's lab at the University of Arizona focuses on the giant protein titin and its role in muscle function and stiffness regulation. They investigate how titin interacts with muscle filaments during contraction and how mutations in this protein can lead to muscle diseases. By using mouse models and various experimental techniques, the lab aims to deepen our understanding of muscle mechanics, which could pave the way for new therapies for muscle-related conditions.
titinmuscle contractionskeletal musclemechanosensingmyopathies
Research Aims
4AIM 01Investigate the role of titin's PEVK and N2A elements in regulating muscle stiffness.
AIM 02Study how titin interacts with thin filaments during muscle contraction.
AIM 03Test the hypothesis that titin-based passive strain activates thick filaments in muscle.
AIM 04Examine the impact of perturbing titin strain on muscle function.
Skills the Lab Values
mouse modelsATP turnover assaysprotein purificationWestern blotimmunofluorescence microscopy
Output against the department
Publications381top 13% of dept.130th of 1,033
this lab
most publishedleast published
Citations17ktop 23% of dept.242nd of 1,033
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.