University of Colorado Boulder · BiochemistryMitochondrial Dynamics and Disease Unit
Ding Xue · Boulder, Colorado
Research Focus
Dr. Ding Xue's lab focuses on understanding how certain biological processes, like the removal of paternal mitochondria in embryos and the effects of radiation on cells, impact development and health. They investigate the mechanisms behind these processes to uncover how defects can lead to diseases, including mitochondrial disorders. The research aims to identify new targets for treatments that could improve outcomes for patients experiencing these issues.
paternal mitochondriabystander effectscell biologymolecular geneticsstress responsedevelopmental biologyhuman diseasestherapeutic targetsproteomicsradiation therapy
Research Aims
5AIM 01Investigate how paternal mitochondria are recognized and eliminated during fertilization.
AIM 02Identify the factors that trigger bystander effects in unexposed cells.
AIM 03Explore the signaling pathways involved in mediating bystander responses.
AIM 04Uncover the genetic mechanisms that regulate paternal mitochondrial elimination.
AIM 05Determine how defects in these processes contribute to human diseases and explore potential therapies.
Skills the Lab Values
PCRcell cultureprotein analysisbiochemical assaysmolecular cloninggenetic manipulationWestern blotmicroscopyradiation biologydata analysis
Output against the department
Publications87bottom 19% of dept.322nd of 402
this lab
most publishedleast published
Citations6.3kbottom 36% of dept.257th of 402
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.