Northwestern University · NeuroscienceSavas Neurodegeneration Lab
Jeffrey Nicholas Savas · Evanston, Illinois
Research Focus
Dr. Jeffrey Nicholas Savas's lab at Northwestern University focuses on understanding the early stages of Alzheimer's disease, particularly the role of amyloid beta plaques in brain degeneration. The lab uses innovative imaging techniques to track how amyloid plaques form and evolve over time in mouse models. This research is vital for uncovering how these plaques contribute to cognitive decline and could inform new treatments for Alzheimer's disease.
Alzheimer's DiseaseAmyloid PlaquesNeurodegenerationSynaptic DysfunctionMulti-omic Mapping
Research Aims
4AIM 01Map the trajectory of amyloid plaque pathology in aging mouse models.
AIM 02Determine the effect of the AD risk factor Trem2 on amyloid dynamics.
AIM 03Integrate multi-omic amyloid maps with synaptic communication measures.
AIM 04Develop 3D mapping techniques for the neuroscience community.
Skills the Lab Values
Confocal MicroscopyMolecular ProfilingMouse ModelsProtein Dynamics AnalysisElectrophysiologyFluorescent LabelingData Set Management3D Mapping TechniquesImaging Analysis
Output against the department
Publications1bottom 1% of dept.666th of 671
this lab
most publishedleast published
Citations78bottom 2% of dept.659th of 671
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.