Case Western Reserve University · BiologyTau Misfolding and Neurodegeneration Lab
Allison L Kraus · Cleveland, Ohio
Research Focus
Dr. Allison Kraus leads a research lab focused on understanding tau misfolding in neurodegenerative diseases like Alzheimer's and other dementias. The lab investigates how tau aggregates form and interact at the cellular level, aiming to identify biomarkers for early diagnosis and to find novel therapeutic targets. Their work combines advanced protein detection techniques with innovative approaches to study brain and skin samples.
Alzheimer's Diseasetau misfoldingneurodegenerationbiomarkersskin diagnosticsprotein aggregationcellular mechanismsRT-QuICPMCA
Research Aims
4AIM 01Identify the distribution and quantity of tau seeds in human brains.
AIM 02Evaluate the cellular factors that influence tau seeding and accumulation.
AIM 03Develop skin-based biomarkers for diagnosing Alzheimer's disease.
AIM 04Investigate the role of glial cells in the propagation of tau seeds.
Skills the Lab Values
RT-QuICprotein misfolding cyclic amplification (PMCA)biochemical assayscellular modelingimmunohistochemistrytranscriptomic analysiscryoelectron microscopymicroenvironment mappingdata analysisproteomics
Output against the department
Publications76bottom 22% of dept.803rd of 1,033
this lab
most publishedleast published
Citations2.8kbottom 20% of dept.822nd of 1,033
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.