University of Nebraska Medical Center · PharmacologyGendelman Lab
Howard E Gendelman · Omaha, Nebraska
Research Focus
Dr. Howard E. Gendelman's research lab focuses on innovative approaches to combat HIV through targeted therapies. They are developing lipid nanoparticles that can deliver gene therapies specifically to HIV-infected cells, aiming to eliminate hidden viral reservoirs. The lab also investigates the effects of HIV on neurodegenerative diseases, particularly Alzheimer's, using specially designed animal models to understand the interplay between viral infection and brain health.
HIVgene therapylipid nanoparticlesneurodegenerationAlzheimer's diseaseCRISPRfocused ultrasoundimmunologyviral eradicationanimal models
Research Aims
5AIM 01Develop targeted lipid nanoparticles for delivering gene therapeutics to eradicate HIV reservoirs
AIM 02Investigate the role of HIV infection in neurodegenerative diseases like Alzheimer's
AIM 03Create a humanized mouse model for studying the effects of HIV on brain health
AIM 04Evaluate the impact of specific immune cell subsets on HIV progression and neurodegeneration
AIM 05Optimize therapeutic strategies to enhance immune response and reduce viral loads in the CNS.
Skills the Lab Values
cell cultureCRISPR-Cas9lipid nanoparticle formulationRNA delivery techniquesmicrobubble-enhanced ultrasoundimmunohistochemistrymouse modelsflow cytometrymagnetic resonance imagingpositron emission tomography
Output against the department
Publications660top 5% of dept.24th of 462
this lab
most publishedleast published
Citations48ktop 5% of dept.23rd of 462
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.