UTMThe University of Texas MD Anderson Cancer Center · Biomedical Engineering
The Lung Enzyme Initiative
Pawel K. Mazur · Houston, Texas
Research Focus
Dr. Pawel K. Mazur’s lab focuses on understanding the roles of specific enzymes in lung cancer progression and treatment. The research investigates the regulation of lung squamous cell carcinoma and small cell lung cancer through the study of epigenetic factors such as NSD3, CARM1, and NSD2. By utilizing advanced mouse models and pharmacological approaches, the lab aims to uncover new therapeutic targets to improve cancer treatments and outcomes for patients.
lung cancerepigeneticsNSD3CARM1NSD2transcription factorssmall cell lung cancerlung adenocarcinomamethylationtumorigenesis
Research Aims
4AIM 01Investigate the role of NSD3 in lung squamous cell carcinoma pathogenesis.
AIM 02Study the therapeutic potential of targeting the CARM1-NFIB axis in small cell lung cancer.
AIM 03Evaluate the NSD2-H3K36me2 axis in lung adenocarcinoma.
AIM 04Test the efficacy of NSD2 inhibition based on preclinical models of lung cancer.
Skills the Lab Values
mouse modelsepigenomic techniquesCRISPRgene expression analysiscell culturebiochemical assaysimmunohistochemistrydrug screeningsingle cell sequencingin vivo experimentation
Output against the department
Publications174bottom 39% of dept.360th of 595
this lab
most publishedleast published
Citations5.7kbottom 44% of dept.336th of 595
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.