PCOPhiladelphia College of Osteopathic Medicine · Biochemistry
Montie Lab
Heather L Montie · Philadelphia, Pennsylvania
Research Focus
Dr. Heather Montie's lab focuses on understanding a neuromuscular disease called spinal and bulbar muscular atrophy (SBMA). The team investigates how a specific enzyme, CD38, can influence energy production in muscle cells, potentially leading to new therapies for SBMA. Using advanced techniques like CRISPR and stem cell technology, they aim to explore metabolic dysfunction in affected individuals and identify clinical interventions.
SBMACD38CRISPRmuscle metabolismtherapeutic targetsneuromuscular diseasemetabolic dysfunctionenergy productionNAD+skeletal muscle
Research Aims
5AIM 01Investigate the role of CD38 in SBMA pathogenesis.
AIM 02Examine metabolic alterations in SBMA patient-derived iPSCs differentiated into skeletal muscles.
AIM 03Test CD38 inhibitors for their potential to restore NAD+ levels in SBMA models.
AIM 04Evaluate the contribution of CD38+ immune cells to NAD+ depletion in muscle tissue.
AIM 05Develop a rationale for future clinical trials targeting CD38 in SBMA patients.
Skills the Lab Values
CRISPRstem cell culturemouse modelsmetabolomicspharmacologic interventionin vivo imagingglycolysis pathway analysismolecular biology techniquesdata analysisanimal handling
Output against the department
Publications27bottom 1% of dept.397th of 402
this lab
most publishedleast published
Citations783bottom 2% of dept.394th of 402
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.