University of North Carolina at Chapel Hill · Biomedical EngineeringPapadopoulou Ultrasonics Lab
Virginie Papadopoulou · Chapel Hill, North Carolina
Research Focus
Dr. Virginie Papadopoulou's lab focuses on developing innovative ultrasound-based therapies to enhance the treatment of chronic wounds, particularly those infected by tough-to-treat bacterial biofilms. By using advanced materials and techniques like phase-change contrast agents and therapeutic ultrasound, they aim to improve antibiotic delivery and effectiveness, reducing infection rates and promoting faster healing. This research has significant implications for public health, especially for individuals with conditions like diabetes that complicate wound healing.
ultrasound therapychronic woundsbiofilmsdrug deliveryantibiotic resistancetheranosticsPseudomonas aeruginosaStaphylococcus aureusdiabetic foot infectionstherapeutic ultrasound
Research Aims
5AIM 01Develop a theranostic ultrasound platform to enhance antibiotic delivery to biofilm-infected wounds.
AIM 02Optimize the use of acoustically responsive particles for improved drug penetration.
AIM 03Evaluate the efficacy of ultrasound in treating polymicrobial infections in chronic wounds.
AIM 04Investigate the mechanisms of action of therapeutic ultrasound on wound pathogens.
AIM 05Predict therapeutic response and adaptation of wound care based on ultrasound activity.
Skills the Lab Values
ultrasound imagingmicrobubble technologyin vitro modelingantibiotic susceptibility testinganimal modelsdata analysiswound healing assaysbacterial culture techniquesbiomaterial developmenttherapeutic response evaluation
Output against the department
Publications99bottom 17% of dept.492nd of 595
this lab
most publishedleast published
Citations1.1kbottom 7% of dept.556th of 595
this lab
most citedleast cited
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