UWMUniversity of Wisconsin-Madison · Biology
Viral Reservoir Dynamics Lab
Matthew R. Reynolds · Madison, Wisconsin
Research Focus
Dr. Matthew R. Reynolds' lab at the University of Wisconsin-Madison focuses on understanding how different sizes of viral reservoirs influence the ability of people with HIV to control the virus after stopping treatment. Using a monkey model, his research aims to clarify the relationship between viral reservoirs, immune responses, and HIV recurrence. This work is crucial for developing effective strategies for HIV cure regimens.
HIV cureviral reservoirsantiviral immunitySIVmonkey model
Research Aims
5AIM 01Determine how the size of SIV viral reservoirs affects time to viral rebound (TTR).
AIM 02Investigate the impact of antiviral immunity on TTR and post-treatment viral control (PTC).
AIM 03Use genetically barcoded SIV to understand reservoir dynamics after stopping ART.
AIM 04Establish a predictive model for viral replication control based on reservoir size.
AIM 05Identify the minimum number of latently infected cells needed for prolonged ART-free remission.
Skills the Lab Values
cell cultureSIV animal modelsPCRviral load quantificationimmunological assays
Output against the department
Publications326top 16% of dept.165th of 1,033
this lab
most publishedleast published
Citations20ktop 19% of dept.198th of 1,033
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.