University of Arkansas for Medical Sciences · NeurosciencePituitary Function and Adaptation Lab
Angus M Macnicol · Little Rock, Arkansas
Research Focus
Dr. Angus M Macnicol's lab at the University of Arkansas for Medical Sciences studies how the anterior pituitary gland adapts to changes in hormonal needs, especially relating to female fertility and aging. The lab focuses on the role of a protein called Musashi, which influences how pituitary cells change and function in response to bodily stress. By understanding these processes, the lab aims to find ways to improve fertility and treat hormone-related disorders.
pituitary plasticityhormonal regulationfemale fertilityMusashi proteincell differentiationagingmetabolic diseaseshormone-producing cells
Research Aims
5AIM 01Investigate the role of Musashi in regulating mRNA translation.
AIM 02Identify molecular mediators of pituitary cell plasticity.
AIM 03Understand the impact of hormonal changes on pituitary function.
AIM 04Explore transcriptional and post-transcriptional control mechanisms in pituitary cells.
AIM 05Assess sex as a variable in hormonal response studies.
Skills the Lab Values
mRNA analysiscell culturegene expression assaysepigenetic analysisWestern blottingbioinformaticstranslational control techniquesanimal modelsflow cytometry
Output against the department
Publications102bottom 34% of dept.440th of 671
this lab
most publishedleast published
Citations2.7kbottom 17% of dept.556th of 671
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.