UWMUniversity of Wisconsin-Madison · Genetics
Pool Evolution Lab
John E Pool · Madison, Wisconsin
Research Focus
Dr. John E Pool's lab at the University of Wisconsin-Madison focuses on understanding how genetic variations contribute to the evolution of traits and the early stages of reproductive isolation using the fruit fly, Drosophila melanogaster. By combining experimental studies and large data analysis, the lab aims to uncover the genetic architectures that drive adaptive evolution and sheds light on how populations diverge. The work is significant not only for evolutionary genetics but also for informing health-related issues like infertility and understanding disease vectors.
adaptive evolutionDrosophilagenetic diversityreproductive isolationpopulation geneticstrait variationgenotype-phenotype mappinggenetic architecturemolecular regulationhybrid incompatibility
Research Aims
5AIM 01Investigate how genomic diversity drives adaptive evolution in Drosophila populations.
AIM 02Identify candidate genes associated with adaptive traits using genotype-phenotype association tests.
AIM 03Examine regulatory traits that link genomes to adaptive changes during evolution.
AIM 04Map genetic incompatibilities affecting hybrid fertility between D. melanogaster populations.
AIM 05Explore the complex isolation history between D. melanogaster and D. simulans to understand evolutionary dynamics.
Skills the Lab Values
PCRgenotype-phenotype association testingpopulation genomicschromatin analysisRNA sequencingdata analysisDrosophila geneticsexperimental designgenetic mappingbioinformatics
Output against the department
Publications95bottom 29% of dept.183rd of 259
this lab
most publishedleast published
Citations7.1kbottom 37% of dept.163rd of 259
this lab
most citedleast cited
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