University at Buffalo · BiochemistryBuck Lab
Michael Joseph Buck · Buffalo, New York
Research Focus
Michael Buck's lab at the University of Buffalo studies how transcription factors (TFs) interact with DNA in our cells. They focus on understanding the rules that govern how these proteins bind to chromatin, which is the material that makes up our chromosomes, particularly when it is tightly packed. By exploring these interactions, the lab seeks to uncover insights into gene expression, which is crucial for normal development and understanding diseases.
transcription factorschromatinnucleosome positioninggene expressionDNA bindinghistone modificationschromatin remodelingbiological processesTF binding sites
Research Aims
3AIM 01Define how transcription factors recognize their binding sites within nucleosomes.
AIM 02Investigate how histone modifications and nucleosome positioning regulate transcription factor binding.
AIM 03Determine how chromatin organization influences transcription factor binding.
Skills the Lab Values
PCRcell cultureWestern blotchromatin immunoprecipitationRNA sequencingin vitro assayscell line developmentbiochemical assaysbioinformatics
Output against the department
Publications149bottom 41% of dept.236th of 402
this lab
most publishedleast published
Citations5.6kbottom 32% of dept.274th of 402
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.