Yale University · Microbiology & ImmunologyLara-Tejero Lab
Maria Lara-Tejero · New Haven, Connecticut
Research Focus
Dr. Maria Lara-Tejero's lab at Yale University studies the machinery that some harmful bacteria use to infect host cells. Her team is focused on understanding how these bacteria inject proteins into host cells, which is crucial for their ability to cause disease. By using advanced imaging and genetic techniques, they seek to uncover details about this process that could help in developing new ways to combat bacterial infections.
Type III secretion systemSalmonellabacterial pathogenesisprotein injectionsuper-resolution microscopycryo-electron microscopybacterial geneticsvirulenceinfectious diseasesnanomachines
Research Aims
5AIM 01Characterize the structure of the Salmonella type III secretion sorting platform.
AIM 02Investigate the mechanism of client protein selection and sorting.
AIM 03Analyze the functional dynamics of the injectisome complex.
AIM 04Study the conservation of T3SS among various pathogenic bacteria.
AIM 05Develop insights into T3SS function to inform anti-infective strategies.
Skills the Lab Values
super-resolution microscopycryo-electron microscopybacterial geneticsprotein purificationcell culturebiochemical assaysmolecular cloningdata visualizationimaging techniquesmicroscopy
Output against the department
Publications61bottom 16% of dept.407th of 486
this lab
most publishedleast published
Citations7.2ktop 49% of dept.239th of 486
this lab
most citedleast cited
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