New York University · BiologyThe Maturation Initiative
Matija Snuderl · New York, New York
Research Focus
Dr. Matija Snuderl's lab at NYU School of Medicine focuses on understanding medulloblastoma, the most common malignant brain tumor in children. The team investigates how certain biological processes can be harnessed to induce maturation in these tumors, making them less aggressive and more treatable. Through advanced techniques in genetics and drug delivery, the lab aims to develop new therapies that are less toxic than current treatments.
medulloblastomaneural maturationEZH2epigeneticstumor therapynanoparticle drug deliverySonic hedgehog pathway
Research Aims
3AIM 01Investigate the molecular mechanisms of spontaneous maturation in medulloblastoma.
AIM 02Identify the role of EZH2 in tumor cell maturation using mouse models.
AIM 03Evaluate the effectiveness and safety of new therapies targeting medulloblastoma vasculature and the SHH pathway.
Skills the Lab Values
animal modelsRNA sequencingepigenetic analysisdrug delivery systemstranscriptomicsmolecular profilinghigh-resolution genomicscell culturein vivo imaging
Output against the department
Publications717top 3% of dept.33rd of 1,033
this lab
most publishedleast published
Citations27ktop 13% of dept.138th of 1,033
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.