The University of Texas Health Science Center at San Antonio · BiologyHealthy Aging and mTOR Research Lab
Ellen Kraig · San Antonio, Texas
Research Focus
Dr. Ellen Kraig's lab focuses on researching how certain drugs, called mTOR inhibitors, can promote healthier aging in older adults. The lab conducts studies to understand how different doses and schedules of these drugs affect the health and biology of elderly individuals. Through careful testing, they aim to determine the safest and most effective ways to use these drugs to improve health outcomes as people age.
mTOR inhibitorshealthy agingpharmacokineticspharmacodynamicsbiomarkersRapamycinEverolimusclinical trialsolder adults
Research Aims
5AIM 01Assess the pharmacokinetic and pharmacodynamic effects of mTOR inhibitors in older adults.
AIM 02Determine the optimal dosing strategies for Rapamycin and Everolimus in elderly subjects.
AIM 03Evaluate the safety and tolerability of optimized doses of mTOR inhibitors in a controlled trial.
AIM 04Collect and analyze biological specimens to assess mTOR pathway activity.
AIM 05Establish a repository for future aging research involving mTOR inhibitors.
Skills the Lab Values
drug dosing strategiespharmacokinetics assessmentbiomarker analysisplacebo-controlled trial designblood and tissue analysissafety assessment measuresdata collection and managementclinical research methodologiesmedical statistics
Output against the department
Publications92bottom 31% of dept.711th of 1,033
this lab
most publishedleast published
Citations3.9kbottom 30% of dept.726th of 1,033
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.