RUThe Rockefeller University · Biochemistry
Roeder Lab
Robert G Roeder · New York, New York
Research Focus
Dr. Robert G. Roeder's lab at Rockefeller University focuses on understanding how specific proteins interact to control the formation and function of fat cells, which play a crucial role in metabolic health. The lab uses a combination of biochemical techniques and animal studies to explore how these interactions can impact conditions like obesity and diabetes. This research aims to uncover new potential treatments for metabolic disorders by examining the underlying mechanisms of fat cell behavior.
adipocytesnuclear receptorstranscriptional controlmetabolismbiochemical interactionsMediator complexobesityGene Regulationtranscription factorsmetabolic diseases
Research Aims
4AIM 01Investigate how nuclear receptors and coactivators interact at gene enhancers to control fat cell identity.
AIM 02Analyze the role of different protein combinations in transcriptional activation of adipocytes.
AIM 03Understand how altering Mediator interactions can influence energy storage and expenditure in fat cells.
AIM 04Identify cellular mechanisms that lead to metabolic advantages in genetically modified mice under obesity-promoting conditions.
Skills the Lab Values
cell cultureChIP-seqRNA polymerase II assaysmass spectrometryanimal modelsgenome editingbiochemical assaystranscription researchmolecular cloning
Output against the department
Publications685top 5% of dept.19th of 402
this lab
most publishedleast published
Citations85ktop 2% of dept.8th of 402
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.