University of Alabama at Birmingham · Microbiology & ImmunologyThe IgA Pathogenesis Lab
Jan Novak · Birmingham, Alabama
Research Focus
Jan Novak's lab at the University of Alabama at Birmingham focuses on understanding the molecular mechanisms involved in IgA nephropathy (IgAN), a leading cause of kidney failure. The research aims to identify the characteristics and biological activities of IgA1-containing immune complexes in patients with this disease. By studying these complexes, the lab seeks to uncover the factors that influence disease progression and develop targeted therapies.
IgA nephropathyimmune complexespathogenicitybiomarkerscomplement system
Research Aims
3AIM 01Determine the biological activity of IgA1 immune complexes in different IgAN patient groups.
AIM 02Analyze the O-glycophenotypes of IgA1 in circulating immune complexes.
AIM 03Investigate the role of complement proteins on the activity of IgA1 immune complexes.
Skills the Lab Values
Western blottingcell culturein vivo modelingenzyme-linked immunosorbent assay (ELISA)molecular sieve chromatography
Output against the department
Publications338top 13% of dept.63rd of 486
this lab
most publishedleast published
Citations22ktop 16% of dept.79th of 486
this lab
most citedleast cited
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