University of Connecticut · NeuroscienceAlzheimer's Research and Therapeutics Lab
Riqiang Yan · Storrs, Connecticut
Research Focus
Dr. Riqiang Yan's lab focuses on understanding the role of the enzyme BACE1 in Alzheimer's disease, particularly how inhibiting this enzyme in glial cells might help reduce harmful amyloid and tau pathologies in the brain. The lab conducts experiments using transgenic mouse models to explore innovative treatments that enhance the immune response of microglia, which are crucial for clearing out these toxic substances. The ultimate goal is to develop safer therapeutic strategies for Alzheimer's patients.
Alzheimer's DiseaseBACE1 InhibitionMicrogliaTransgenic MiceAmyloid ClearanceTau Pathology
Research Aims
3AIM 01Investigate the effects of deleting BACE1 in microglia on tau pathology.
AIM 02Assess whether low dose BACE1 inhibition combined with microglial deletion reduces amyloid and tau pathologies.
AIM 03Explore the role of CXCL14 in promoting microglial function and amyloid clearance.
Skills the Lab Values
Mouse ModelsGenetic EngineeringPhagocytosis AssaysImmunohistochemistryCell CulturePCRBehavioral TestingRNA Analysis
Output against the department
Publications182top 41% of dept.277th of 671
this lab
most publishedleast published
Citations12ktop 34% of dept.229th of 671
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.