Harvard University · Microbiology & ImmunologyChromosome Dynamics and Organization Lab
Nancy E Kleckner · Cambridge, Massachusetts
Research Focus
Dr. Nancy Kleckner's lab at Harvard University studies how chromosomes behave and organize themselves during important processes like cell division and reproduction. By examining both yeast and E. coli, the team explores the similarities between meiotic (sexual reproduction) and mitotic (cell division) chromosomes, looking for common patterns and mechanisms. Their work has implications for understanding infertility, cancer, and antibiotic resistance.
chromosome organizationmeiosismitosisE. colirecombinationcell divisionchromatin dynamicsnucleoidmechanical stresslive imaging
Research Aims
5AIM 01Investigate the behaviors and functions of meiotic and mitotic chromosomes.
AIM 02Analyze how chromosomes interact and recombine during meiosis.
AIM 03Examine nucleoid dynamics in E. coli and their impact on cell division.
AIM 04Develop tools to visualize mechanical stress in chromosomes.
AIM 05Explore the role of protein phosphatase PP2A in chromosome patterning and stress transduction.
Skills the Lab Values
4D imagingfluorescence microscopylive cell trackingassay developmentgenetic manipulation in yeastanalysis of chromosome dynamicsstress pattern sensingbioinformaticscell culture techniquesE. coli manipulation
Output against the department
Publications231top 27% of dept.131st of 486
this lab
most publishedleast published
Citations36ktop 7% of dept.35th of 486
this lab
most citedleast cited
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