University of Vermont · BiologyJanssen-Heininger Lab
Yvonne M. W. Janssen-Heininger · Burlington, Vermont
Research Focus
Dr. Yvonne M. W. Janssen-Heininger's lab at the University of Vermont studies lung cancer, focusing on how a molecular process involving a protein called glutaredoxin affects cancer cell survival and resistance to treatment. The lab is investigating how changes in glutathione metabolism can influence lung tumor growth and how these insights can lead to potential new therapies for lung cancer patients. By understanding the cancer's metabolic adaptations, the lab aims to develop strategies to enhance the effectiveness of existing treatments like cisplatin.
lung cancerglutathioneredox signalingKRAS mutationstherapeutic strategies
Research Aims
3AIM 01Investigate the role of glutaredoxin in KRAS-induced lung cancer tumor growth.
AIM 02Explore the relationship between S-glutathionylation and glutamine metabolism in lung tumors.
AIM 03Evaluate the potential of AAV-mediated gene therapy to enhance cisplatin efficacy in lung cancer.
Skills the Lab Values
molecular cloningcell culturemouse modelsglutathione assaysredox proteomics
Output against the department
Publications218top 29% of dept.295th of 1,033
this lab
most publishedleast published
Citations11ktop 32% of dept.331st of 1,033
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.