USUUtah State University · Biology
Wang Hepatitis Lab
Zhongde Wang · Logan, Utah
Research Focus
Dr. Zhongde Wang's lab at Utah State University focuses on developing a new hamster model for studying hepatitis B virus (HBV) infection. This research aims to create an immunocompetent animal model that closely mimics human HBV infections, which is vital for testing potential cures for chronic HBV. By using advanced genetic techniques, the lab hopes to enhance our understanding of HBV pathogenesis and evaluate innovative therapeutic approaches.
Hepatitis B virusanimal modelhamster modelHBV infectionimmunocompetentgene editingtherapeuticshumoral immune responsesantiviral agentschronic HBV infection
Research Aims
3AIM 01Establish a humanized-NTCP hamster model for HBV infection.
AIM 02Characterize the pathogenesis and humoral immune responses during HBV infections in hamsters.
AIM 03Test the efficacy of various antiviral and immunomodulatory treatments in the hamster model.
Skills the Lab Values
CRISPR gene editinganimal handlingviral infection techniquespathogenesis studiesimmunological assayscell culturedrug efficacy testingHepatocyte isolationRNA extractionmolecular cloning
Output against the department
Publications152top 44% of dept.456th of 1,033
this lab
most publishedleast published
Citations6.7kbottom 47% of dept.547th of 1,033
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.