The University of Texas Medical Branch at Galveston · BiologyThe GlycoViral Initiative
Slobodan Paessler · Galveston, Texas
Research Focus
Dr. Slobodan Paessler's lab focuses on understanding and combating arenavirus infections, which cause serious diseases like hemorrhagic fevers. The team is investigating how these viruses rely on certain sugars, namely D-glucose and D-mannose, to survive and replicate. By exploring innovative antiviral strategies, including the use of sugar mimetics, the lab aims to develop new treatment options that could protect against outbreaks and save lives.
arenavirushemorrhagic feverantiviral agentsD-glucoseD-mannoseantimetabolitessugar mimeticspublic healthglycolysispreclinical evaluation
Research Aims
3AIM 01Investigate the impact of WP1096 and 2-DG on glycolysis and viral glycoproteins in infected cells.
AIM 02Conduct in vivo evaluations of WP1096, including studies on toxicology and pharmacokinetics.
AIM 03Assess the protective efficacy of WP1096 and 2-DG in vivo, focusing on their effects on glycosylation and the host glycolysis pathway.
Skills the Lab Values
cell culturein vivo toxicology studiespharmacokineticsmolecular probingisotope labelingglycoprotein analysismonosaccharide metabolismanimal handlingWestern blottingmass spectrometry
Output against the department
Publications210top 31% of dept.318th of 1,033
this lab
most publishedleast published
Citations6.2kbottom 45% of dept.568th of 1,033
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.