University of Miami · BiologySIRT5 Targeting Lab
David Benner Lombard · Coral Gables, Florida
Research Focus
David Benner Lombard's lab at the University of Miami focuses on researching Ewing sarcoma, a serious childhood cancer. The lab investigates a molecule called SIRT5 to see if it can be targeted to improve treatments, especially for patients who have the most aggressive forms of the disease. The aim is to create new drugs that can effectively kill Ewing sarcoma cells while minimizing side effects for patients.
Ewing sarcomaSIRT5cancer treatmenttherapeuticsgene expression
Research Aims
2AIM 01Investigate how SIRT5 affects histone modifications and gene expression in Ewing sarcoma.
AIM 02Develop and validate inhibitors and degraders of SIRT5 to explore its therapeutic potential.
Skills the Lab Values
mass spectrometrycell culturemedicinal chemistrytranscriptomicsepigenomics
Output against the department
Publications234top 26% of dept.270th of 1,033
this lab
most publishedleast published
Citations21ktop 18% of dept.190th of 1,033
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.