Middle Tennessee State University · BiologyCancer Genetics and Tumor Biology Lab
April M. Weissmiller · Murfreesboro, Tennessee
Research Focus
Dr. April M. Weissmiller's lab focuses on understanding how certain mutations in cancer-related proteins affect tumor development, specifically looking at the interplay between the SWI/SNF complex and the MYC oncoprotein. The lab investigates how these connections influence gene expression in cancer cells lacking a specific protein called BRG1. By examining these relationships, the lab aims to uncover new mechanisms behind cancer progression, potentially leading to better approaches for treatment.
SWI/SNF complexMYC oncoproteinBRG1cancer geneticstumor suppression
Research Aims
5AIM 01Determine how MYC and SWI/SNF regulate genomic activities in BRG1-null cancer cells.
AIM 02Investigate the role of BRG1 in modulating MYC function across the genome.
AIM 03Uncover oncogenic mechanisms that maintain BRG1-null cancer states.
AIM 04Challenge the significance of SWI/SNF in controlling MYC target gene expression.
AIM 05Explore the interactions between MYC and SWI/SNF subunits in cancer cells.
Skills the Lab Values
genetic analysisgenomic sequencingcell culture techniquesRNA-sequencingmolecular cloninggenetic modificationbiological assaystumor cell line modeling
Output against the department
Publications41bottom 8% of dept.943rd of 1,033
this lab
most publishedleast published
Citations1.5kbottom 9% of dept.935th of 1,033
this lab
most citedleast cited
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