Northwestern University · PhysiologyParkinson's Disease Neurodegeneration Lab
Mark D Bevan · Evanston, Illinois
Research Focus
Dr. Mark D. Bevan's research lab at Northwestern University focuses on understanding the degeneration of neurons in Parkinson's disease and its effects on movement. The lab uses a genetic mouse model to study how brain circuits function during different stages of the disease. They explore potential therapies that might restore normal brain activity and prevent further degeneration of neurons, which could help improve motor function in individuals affected by Parkinson's disease.
Parkinson's diseasebasal ganglianeurodegenerationmouse modelsmotor dysfunctioncircuit plasticitychemogeneticselectrophysiologyoptogenetics
Research Aims
3AIM 01Examine the mechanisms responsible for retention of motor function in prodromal Parkinson's disease mice.
AIM 02Investigate the progressive dysfunction of motor pathways in symptomatic Parkinson's disease mice.
AIM 03Test if manipulating brain circuits can rescue movement and prevent neuron degeneration in Parkinson's disease.
Skills the Lab Values
in vivo electrophysiologyoptogeneticschemogenetics2-photon imagingimmunohistochemistrybehavioural assaysgenetic manipulationmouse model developmentdata analysis
Output against the department
Publications65bottom 12% of dept.250th of 286
this lab
most publishedleast published
Citations7.6ktop 43% of dept.124th of 286
this lab
most citedleast cited
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