Rutgers University-New Brunswick · BiologyAdeno-Associated Virus Research Lab
Jason T Kaelber · New Brunswick, New Jersey
Research Focus
Dr. Jason T. Kaelber's lab at Rutgers focuses on improving gene therapies that use adeno-associated viruses (AAV). They are exploring the detailed mechanisms of how these viruses infect cells and package their genetic material, which could lead to more effective therapies with fewer side effects. By applying advanced imaging techniques, the lab aims to directly visualize viral interactions at the molecular level to address the challenges associated with AAV gene therapy.
Adeno-Associated VirusGene TherapyCryo-Electron MicroscopyNanoimagingViral Infection
Research Aims
5AIM 01Investigate the mechanisms of AAV genome delivery to the nucleus.
AIM 02Identify structural differences in virions that successfully deliver genomes versus those that do not.
AIM 03Evaluate the impact of genetic and chemical interventions on AAV genome packaging.
AIM 04Visualize viral particles at various infection stages using advanced imaging techniques.
AIM 05Enhance the understanding of factors limiting the efficiency of AAV gene therapy.
Skills the Lab Values
Cryo-Electron TomographyCryo-Focused Ion Beam MicromachiningCell CultureFluorescence MicroscopyMolecular Cloning
Output against the department
Publications79bottom 23% of dept.793rd of 1,033
this lab
most publishedleast published
Citations1.8kbottom 12% of dept.911th of 1,033
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.