University of Michigan-Ann Arbor · ChemistryTranscription Regulation and Therapeutics Lab
Anna K. Mapp · Ann Arbor, Michigan
Research Focus
Dr. Anna K. Mapp's research lab focuses on understanding how certain proteins control the initiation of gene transcription, which is crucial for processes like cell growth and development. They study the interactions between transcriptional activators and coactivators, which can be targeted for new drug development, especially for diseases like cancer and intellectual disabilities. The lab aims to create synthetic molecules that can either enhance or inhibit these protein interactions, potentially leading to innovative therapeutic solutions.
transcriptional activationprotein-protein interactionsdrug discoverycancer biologyintellectual disability
Research Aims
5AIM 01Investigate the molecular recognition principles of transcriptional activator-coactivator complexes.
AIM 02Develop synthetic inhibitors and enhancers of transcriptional circuits dysregulated in disease.
AIM 03Explore the druggability of protein-protein interaction networks involved in transcription.
AIM 04Conduct in vitro and cellular assays to assess the effects of newly developed molecules on transcription initiation.
AIM 05Create resources for the broader scientific community to facilitate therapeutic development.
Skills the Lab Values
protein purificationcell culturein vitro assaysCRISPRhigh-throughput screeningchemical biology techniquesmolecular cloningbioinformaticsbiophysical characterizationtranscriptional profiling
Output against the department
Publications157bottom 38% of dept.133rd of 216
this lab
most publishedleast published
Citations3.4kbottom 24% of dept.164th of 216
this lab
most citedleast cited
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