The University of Alabama · ChemistryOvarian Cancer Proteomics Lab
Si Wu · Tuscaloosa, Alabama
Research Focus
Dr. Si Wu's lab focuses on developing advanced techniques to analyze proteins in ovarian cancer tissues, particularly using spheroids derived from patient samples. The goal is to create personalized proteome maps that help understand cancer progression and treatment resistance, which can lead to more effective therapies for patients. This innovative research aims to change how we study and treat cancers by utilizing high sensitivity techniques for protein analysis.
Ovarian CancerProteomicsTop-down ProteomicsPhosphoproteomicsPersonalized MedicineBiomarker IdentificationChemoresistanceUltrasensitive TechniquesSpheroid Culture
Research Aims
4AIM 01Develop a 2D-RPLC-CE-MS/MS platform for global intact proteoform screening from spheroids.
AIM 02Create a 3D-IMAC-RPLC-CE-MS/MS platform for low abundance intact phosphoproteoform screening from spheroids.
AIM 03Generate personalized proteome maps from individual ovarian cancer spheroids to identify chemoresistance markers.
AIM 04Integrate advances in mass spectrometry to enhance the sensitivity of protein detection in cancer research.
Skills the Lab Values
Capillary ElectrophoresisMass SpectrometryLiquid ChromatographyProtein AnalysisCell Culture TechniquesBiomarker DiscoveryData BenchmarkingAnalytical Chemistry TechniquesSpheroid Isolation
Output against the department
Publications285top 39% of dept.85th of 216
this lab
most publishedleast published
Citations11ktop 45% of dept.98th of 216
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.