UTHThe University of Texas Health Science Center at Houston · Neuroscience
Urayama Lab
Akihiko Urayama · Houston, Texas
Research Focus
Dr. Akihiko Urayama's lab at the University of Texas Health Science Center Houston focuses on understanding the safety and effectiveness of immunotherapy for Alzheimer's disease. They study how certain antibodies can clear harmful amyloid-beta proteins from the brain while avoiding dangerous side effects like inflammation and bleeding. The lab aims to develop strategies that maximize treatment benefits while minimizing risks for patients.
Alzheimer's diseaseimmunotherapyamyloid-betavascular inflammationchimeric antibodies
Research Aims
3AIM 01Identify the clearance pathways of anti-amyloid antibodies in Alzheimer's disease models.
AIM 02Examine the development of ARIA events in mice receiving chronic antibody administration.
AIM 03Investigate the inflammatory mechanisms that exacerbate amyloid deposition in immunotherapy-treated mice.
Skills the Lab Values
mouse modelsimmunohistochemistryflow cytometrymagnetic resonance imagingmolecular cloning
Output against the department
Publications64bottom 16% of dept.558th of 671
this lab
most publishedleast published
Citations2.0kbottom 13% of dept.585th of 671
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.