UWMUniversity of Wisconsin-Madison · Biology
Islet Communication and Function Lab
Barak Blum · Madison, Wisconsin
Research Focus
Barak Blum's research lab at the University of Wisconsin-Madison focuses on understanding the islets of Langerhans, which play a critical role in insulin regulation and diabetes. The lab explores how changes in cell communication and tissue architecture during islet expansion impact their ability to function properly, especially in the context of type 2 and gestational diabetes. By investigating the Slit-Robo signaling pathway, the lab aims to uncover new ways to promote healthy islet function and improve glucose regulation in people at risk of diabetes.
islet of Langerhanstype 2 diabetesinsulin regulationcell-cell communicationtissue architectureSlit-Robo signalingpancreatic stromahormone secretiongestational diabetescompensatory expansion
Research Aims
3AIM 01Investigate how Robo2 receptor down-regulation in beta cells affects islet expansion.
AIM 02Determine the consequences of Robo2 down-regulation on alpha cell function.
AIM 03Assess the role of Slit-Robo signaling between pancreatic stroma and endocrine cells in islet dynamics.
Skills the Lab Values
tissue culture3D imagingmolecular biology techniquesmouse modelsin vivo experimentationcell signaling analysisimmunofluorescencegene expression profilingflow cytometrymicroscopy
Output against the department
Publications41bottom 8% of dept.942nd of 1,033
this lab
most publishedleast published
Citations2.9kbottom 22% of dept.805th of 1,033
this lab
most citedleast cited
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