Columbia University in the City of New York · BiologyThe Astrocyte Initiative
Osama Al Dalahmah · New York, New York
Research Focus
Dr. Osama Al Dalahmah's lab at Columbia University focuses on understanding the role of astrocytes, a type of brain cell, in Alzheimer's disease. They are particularly interested in a protein called CD44 that is expressed in these cells and how it may influence the progression of the disease. The lab uses various experimental techniques to study astrocytes in both lab settings and animal models to identify potential new treatments for Alzheimer's.
Alzheimer's diseaseastrocytesCD44neuroinflammationneurodegenerationcellular modelsneuron-astrocyte interactionRNA sequencingtherapeutic targets
Research Aims
3AIM 01Investigate how CD44 alters the function and phenotype of astrocytes in vitro.
AIM 02Study the effects of astrocytic CD44 on neuronal survival and function in Alzheimer's disease models.
AIM 03Examine the in vivo impact of modifying CD44 in an Alzheimer's mouse model to assess neurodegenerative outcomes.
Skills the Lab Values
cell culturegenetic manipulationCRISPRRNA sequencingmultiplex immunofluorescencemouse modelsbehavioral assaysco-culture techniquesdata analysistranscriptomic profiling
Output against the department
Publications74bottom 21% of dept.811th of 1,033
this lab
most publishedleast published
Citations2.2kbottom 15% of dept.874th of 1,033
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.