UWMUniversity of Wisconsin-Madison · Biology
The Hematopoiesis Hub
Emery H. Bresnick · Madison, Wisconsin
Research Focus
Dr. Emery H. Bresnick's lab at the University of Wisconsin-Madison focuses on understanding how specific genetic factors (GATA factors) regulate blood cell development. The research aims to uncover the mechanisms that control the behavior of blood stem cells and how genetic variations can lead to diseases like acute myeloid leukemia (AML) and myelodysplastic syndromes (MDS). Through innovative models and genetic assessments, the lab seeks to improve strategies for diagnosing and treating blood-related disorders.
GATA factorshematopoiesisstem cellsacute myeloid leukemiamyelodysplastic syndromesgenetic variationenhancersgranulopoiesisclinical genetics
Research Aims
3AIM 01Test models to explain how hematopoietic progenitor genome function is established and maintained.
AIM 02Elucidate how a pathogenic GATA2 germline genetic variant retains activity at a subset of GATA2-regulated loci.
AIM 03Generate a human GATA2 genetic curation system to unveil mechanisms and advance clinical genetics.
Skills the Lab Values
genetic curationmouse modelsmulti-omicsDNA binding assayschromatin analysishuman geneticscell culturegene editingflow cytometry
Output against the department
Publications242top 25% of dept.257th of 1,033
this lab
most publishedleast published
Citations9.7ktop 39% of dept.401st of 1,033
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.