New York University · BiologyLi Lab
Fei Li · New York, New York
Research Focus
Dr. Fei Li's research lab focuses on understanding the centromere, an essential chromatin domain that plays a crucial role in proper chromosome segregation during cell division. By exploring how centromeres are specified and inherited, the lab aims to uncover the molecular mechanisms behind centromere function, which is linked to various diseases, including cancer and Down syndrome. Using the fission yeast model, the lab combines different disciplines such as genetics, genomics, and structural biology to investigate the intricacies of centromere organization and regulation.
centromereepigeneticschromosome segregationfission yeastheterochromatinCENP-Acancer3D genome architecturecell divisionmolecular biology
Research Aims
3AIM 01Investigate the regulation of centromere transcription and its impact on centromere function.
AIM 02Examine the organization of heterochromatin repeats and their role in CENP-A assembly.
AIM 03Identify mechanisms behind the spatial organization of centromeres and heterochromatin.
Skills the Lab Values
geneticsgenomicsbiochemistryCENP-A chromatin assemblycell culturemicroscopystructural biologytranscription regulationcytologydata analysis
Output against the department
Publications352top 14% of dept.148th of 1,033
this lab
most publishedleast published
Citations9.1ktop 42% of dept.432nd of 1,033
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.