University of Virginia-Main Campus · BiochemistryMohi Lab
Golam Mohi · Charlottesville, Virginia
Research Focus
Dr. Golam Mohi's lab focuses on understanding the molecular mechanisms behind specific blood disorders called myeloproliferative neoplasms and myelodysplastic syndromes. They study how certain gene mutations lead to abnormal blood cell production and increased risk of cancer. The goal is to identify new therapeutic strategies to improve treatment options for these conditions.
myeloproliferative neoplasmsmyelodysplastic syndromesJAK2V617F mutationU2AF1 mutationsbone marrow fibrosishematopoietic stem cellstumor suppressor genessplicing factorsnew therapeutic targets
Research Aims
3AIM 01Investigate the biological and molecular basis for the synergy between PTPN1 deficiency and JAK2V617F mutation in myeloproliferative neoplasms.
AIM 02Examine the role of TIMP-1 in the progression of myeloproliferative neoplasms induced by JAK2V617F.
AIM 03Identify and test new therapeutic strategies for myeloproliferative neoplasms and myelodysplastic syndromes.
Skills the Lab Values
mouse modelsgene editingRNA sequencingcell cultureWestern blotPCRflow cytometrymolecular biology techniquesbioinformatics
Output against the department
Publications56bottom 10% of dept.361st of 402
this lab
most publishedleast published
Citations1.1kbottom 3% of dept.391st of 402
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.