Icahn School of Medicine at Mount Sinai · GeneticsHIV Vaccine Innovation Lab
Yizhou Dong · New York, New York
Research Focus
Dr. Yizhou Dong's lab focuses on developing new vaccine strategies to combat HIV by combining nanoparticles and engineered mRNA. They aim to create innovative vaccine candidates that can stimulate strong immune responses, potentially offering protection against HIV. By exploring the design of adjuvants and immunogens, the lab works to improve vaccine efficacy and lay the groundwork for future applications in other emerging diseases.
HIV vaccinenanoparticlesmRNA engineeringimmunologyadjuvants
Research Aims
3AIM 01Synthesize and characterize adjuvant derived nanoparticles (ANPs) for HIV vaccine delivery.
AIM 02Engineer mRNA transcripts encoding HIV immunogens to enhance translation efficiency.
AIM 03Evaluate the immunogenicity and safety of ANPs-mRNA in mouse and non-human primate models.
Skills the Lab Values
mRNA synthesisnanoparticle characterizationanimal modelsimmunogenicity assessmentprotein expression analysis
Output against the department
Publications151bottom 49% of dept.133rd of 259
this lab
most publishedleast published
Citations15ktop 38% of dept.98th of 259
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.