University of Pennsylvania · BiologyCancer Proteomics and Therapy Lab
Donita C Brady · Philadelphia, Pennsylvania
Research Focus
Dr. Donita C. Brady's lab at the University of Pennsylvania focuses on understanding cancer biology through a novel approach that combines chemistry and biology. The lab is developing a platform called Probe Enabled Activity Reporting (PEAR) to analyze dynamic changes in the tumor proteome, with the aim of improving targeted therapies and precision oncology. By studying cancer at the proteome level, the lab aims to enhance our understanding of how tumors adapt to therapies and identify new treatment strategies.
cancer biologyproteomicsprecision oncologychemical biologytumor microenvironmenttherapeutic responseepigenetic reprogrammingreactome profiling
Research Aims
5AIM 01Develop innovative methodologies to profile the cancer proteome.
AIM 02Understand the molecular complexity of tumor cell adaptations to therapy.
AIM 03Identify reactive protein targets related to therapeutic response.
AIM 04Validate new concepts and methodologies for solid tumor research.
AIM 05Transform precision oncology through novel drug discovery platforms.
Skills the Lab Values
proteome analysischemical probe developmentpatient-derived cancer modelsbiochemical assayscell cultureprotein visualizationdata analysis using Pythonsignal pathway assessmentepigenetic modification techniques
Output against the department
Publications127bottom 45% of dept.559th of 1,033
this lab
most publishedleast published
Citations5.7kbottom 42% of dept.599th of 1,033
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.