University of Michigan-Ann Arbor · Mathematics & StatisticsThe Genomic Dynamics Lab
Alan P Boyle · Ann Arbor, Michigan
Research Focus
Dr. Alan P. Boyle's lab at the University of Michigan focuses on predicting how variations in DNA affect the behavior of cells. By integrating cutting-edge single-cell technologies with genetic data, the lab aims to create models that show how genetic differences might lead to disease states. This research has important implications for genomic medicine, helping to understand individual and population health based on genetic information.
genomic medicinecellular statesgenetic variationsingle-cell technologiespredictive modelingphenotype associationstranscriptomicsepigenomics
Research Aims
4AIM 01Develop computational methods to predict cellular state changes due to genetic variation.
AIM 02Integrate diverse biological data to enhance predictive modeling of genotype-phenotype relationships.
AIM 03Create an atlas linking genetic variants to cellular phenotypes.
AIM 04Analyze single-cell data to identify disease-related cellular shifts.
Skills the Lab Values
single-cell RNA sequencingdata analysisbioinformaticsstatistical modelingepigenomic profilinggenetic variant annotationmachine learningdata visualizationPython programming
Output against the department
Publications157bottom 32% of dept.89th of 131
this lab
most publishedleast published
Citations24ktop 22% of dept.29th of 131
this lab
most citedleast cited
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