University of Texas Southwestern Medical Center · PhysiologyWu Lab
Jiang Wu · Dallas, Texas
Research Focus
Dr. Jiang Wu's lab at UT Southwestern focuses on understanding how changes at the chromatin level affect neuron activity and brain function. By studying the role of a chromatin regulator called BRG1, the lab investigates how neuronal stimulation can lead to long-lasting changes in gene expression, contributing to neural plasticity and conditions like drug addiction. Students in this lab will learn about the intricate mechanisms of gene regulation and how they pertain to brain health and diseases.
chromatin regulationneuronal plasticitygene expressionepigenetic memoryBRG1cocaineneurodevelopmental disorderscohesinneuron activity
Research Aims
3AIM 01Investigate how neuronal activity-induced BRG1 phosphorylation regulates enhancer priming at the chromatin level.
AIM 02Study the role of cohesin in BRG1 phosphorylation-dependent gene regulation of neuronal activity.
AIM 03Examine the influence of BRG1 phosphorylation on gene activation related to cocaine exposure.
Skills the Lab Values
Chromatin immunoprecipitation (ChIP)Genomic sequencingWestern blottingMouse genetic modelsCell culture techniquesElectrophoretic mobility shift assay (EMSA)Fluorescence microscopyPhosphorylation site analysisBehavioral assays in mice
Output against the department
Publications465top 6% of dept.18th of 286
this lab
most publishedleast published
Citations18ktop 16% of dept.47th of 286
this lab
most citedleast cited
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