University of California-Los Angeles · GeneticsEisenberg Neurobiology Lab
David Eisenberg · Los Angeles, California
Research Focus
In David Eisenberg's lab at UCLA, researchers focus on developing new treatments for Alzheimer’s Disease by studying the structures of toxic proteins in the brain. They utilize advanced imaging techniques to uncover the shapes of these protein aggregates, which contribute to dementia. The lab aims to design drugs that can disrupt and dissolve these harmful aggregates while testing their effectiveness in lab-grown mini-brains, offering a more relevant model for human brain health.
Alzheimer's DiseaseTau proteinsbeta-amyloiddrug designprotein aggregationstructure-based designcryogenic electron microscopyorganoid modelsmini-brains
Research Aims
5AIM 01Identify drug candidates that can disaggregate Tau fibrils
AIM 02Determine the structures of toxic Tau and beta-amyloid oligomers
AIM 03Evaluate the efficacy of AD drug candidates in human cell-based mini-brain models
AIM 04Collaborate to discover compounds that penetrate the brain for treating AD
AIM 05Investigate the behavior of Tau in mouse models to enhance drug testing.
Skills the Lab Values
cryogenic electron microscopyprotein purificationdrug screeningcell culturesmall molecule designorganoid cultureantibody developmentX-ray diffractioncompound characterization
Output against the department
Publications743top 6% of dept.16th of 259
this lab
most publishedleast published
Citations86ktop 6% of dept.15th of 259
this lab
most citedleast cited
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