SLUSaint Louis University · Chemistry
Znosko RNALab
Brent Znosko · Saint Louis, Missouri
Research Focus
Dr. Brent Znosko's lab at Saint Louis University focuses on RNA research, particularly understanding how RNA structures form and behave. The lab seeks to improve the prediction of RNA secondary and tertiary structures based on sequence data, which can help in fields such as therapeutics and biomedical research. By studying the thermodynamics of RNA and analyzing its structural motifs, the lab aims to provide essential insights that can impact a wide range of biological applications.
RNAthermodynamicssecondary structuretertiary structureNMRX-ray crystallographystructure predictionbiomedical sciences
Research Aims
5AIM 01Derive improved nearest neighbor parameters for predicting RNA stability.
AIM 02Identify structural patterns in solved RNA 3D structures.
AIM 03Develop rapid methods to predict RNA structures from sequences.
AIM 04Analyze the thermodynamics of RNA secondary structure motifs.
AIM 05Enhance RNA sequence understanding relevant for therapeutic applications.
Skills the Lab Values
optical melting experimentsNMR spectroscopyX-ray crystallographythermodynamic parameter derivationbioinformatics tool developmentstructure analysisRNA sequence analysisdata analysisscientific writing
Output against the department
Publications61bottom 10% of dept.195th of 216
this lab
most publishedleast published
Citations1.1kbottom 9% of dept.197th of 216
this lab
most citedleast cited
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