University of California-San Francisco · PharmacologyHernandez Genetics Lab
Ryan D. Hernandez · San Francisco, California
Research Focus
Dr. Ryan D. Hernandez's lab focuses on human genetics and evolution, particularly how genetic ancestry affects complex traits across diverse populations. The lab utilizes an extensive dataset from the Trans-Omics for Precision Medicine project to investigate genetic variations and their implications for human health. Their research integrates evolutionary theory with modern computational methods to address pressing questions related to health disparities and precision medicine.
genetic ancestrycomplex traitsevolutionary geneticspopulation geneticsTrans-Omicshuman diversityprecision medicinemutation dynamicsgenetic variation
Research Aims
5AIM 01Investigate how race, ethnicity, and genetic ancestry influence complex traits
AIM 02Analyze the impact of recessive deleterious alleles on genetic variation
AIM 03Develop refined genetic relatedness groups through ancestral recombination graphs
AIM 04Build simulation tools to study the interactions of genetic and non-genetic factors
AIM 05Enhance understanding of evolutionary mechanisms driving phenotypic diversity.
Skills the Lab Values
whole genome sequencing (WGS)RNA sequencing (RNA-seq)data analysisgenome annotationsimulation of genetic traitshaplotype analysisbiostatisticspopulation modelingbioinformatics
Output against the department
Publications195top 45% of dept.206th of 462
this lab
most publishedleast published
Citations44ktop 6% of dept.27th of 462
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.