University of Alabama at Birmingham · Microbiology & ImmunologyWahl Myeloid Lab
Angela Raquel Wahl · Birmingham, Alabama
Research Focus
Dr. Angela Raquel Wahl's lab focuses on understanding the role of myeloid cells, particularly microglia, in the persistence of HIV in the brain. By studying these cells in a humanized mouse model, her research aims to uncover how HIV might hide in the brain, avoid eradication strategies, and lead to complications in patients even when treated with antiretroviral therapy. Ultimately, this work seeks to contribute to the development of more effective HIV cure strategies that can target the central nervous system.
HIV persistencemyeloid cellsmicrogliahumanized mouse modelsHIV latencyneurocognitive disordersviral reservoirbrain HIV infectionsHIV cure strategies
Research Aims
5AIM 01Investigate the role of microglia in HIV latency and persistence in the brain.
AIM 02Analyze the viral reservoir within infected myeloid cells.
AIM 03Understand the impact of ART on HIV suppression in human microglia.
AIM 04Examine the reactivation of HIV after stopping antiretroviral therapy.
AIM 05Develop innovative experimental models to study HIV persistence in the brain.
Skills the Lab Values
cell cultureanimal modelsPCRHIV infection analysisflow cytometryimmunohistochemistryRNA sequencingWestern blotneuroanatomical techniques
Output against the department
Publications24bottom 4% of dept.466th of 486
this lab
most publishedleast published
Citations272bottom 3% of dept.473rd of 486
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.