Case Western Reserve University · GeneticsThe T Cell Nexus
Drew James Adams · Cleveland, Ohio
Research Focus
Dr. Drew James Adams' lab focuses on developing targeted therapies for autoimmune diseases by understanding how T cells become pathologically activated. The research is based on selective inhibitors that can modulate T cell function without broadly suppressing the immune system, potentially leading to treatments with fewer side effects. The lab investigates the molecular mechanisms of these inhibitors and aims to optimize their efficacy in managing diseases like rheumatoid arthritis and graft-versus-host disease.
T Cell ActivationAutoimmune DiseasesSelective InhibitorsExportin-1PharmacologyImmunomodulationCancer TherapeuticsMedicinal ChemistryBiochemical Assays
Research Aims
4AIM 01Understand how small molecules targeting XPO1 affect T cell activation.
AIM 02Explore the cellular mechanisms by which XPO1 modulators inhibit T cell responses.
AIM 03Optimize the pharmacological profile of XPO1 partial antagonists using medicinal chemistry techniques.
AIM 04Evaluate the effects of leading compounds in preclinical models of T cell function.
Skills the Lab Values
Cell CultureHigh-Throughput ScreeningMolecular Biology TechniquesMedicinal ChemistryIn Vivo Mouse ModelsBiochemical AssaysStructural BiologyProtein Binding AssaysData Analysis with Python