University of Maryland, Baltimore · Microbiology & ImmunologyBruno Mycology Lab
Vincent Michael Bruno · Baltimore, Maryland
Research Focus
Dr. Vincent Michael Bruno's lab focuses on understanding and treating mucormycosis, a serious fungal infection that can be life-threatening, especially for individuals with weakened immune systems. The lab explores how certain pathways in host cells, specifically those responding to low oxygen levels, contribute to the infection's progression. The aim is to find new therapeutic strategies that improve survival rates and reduce the severe health impacts associated with this disease.
Mucormycosisfungal infectionhypoxia-response pathwayANGPTL4antifungal therapysingle cell RNA-seqpulmonary infectionimmune responsetherapeutic targeting
Research Aims
3AIM 01Investigate the role of ANGPTL4 in the pathogenesis of mucormycosis.
AIM 02Identify transcriptional targets of the hypoxia-response pathway affected during Mucorales infection.
AIM 03Evaluate the effectiveness of novel therapeutic strategies in conjunction with existing antifungal treatments.
Skills the Lab Values
mouse modelscell culturesingle cell RNA sequencingWestern blotanimal modelspathway analysisin vitro assaysgene expression analysismolecular cloning