Yale University · BiochemistryDe La Cruz Lab
Enrique M De La Cruz · New Haven, Connecticut
Research Focus
Dr. Enrique M De La Cruz's lab at Yale University focuses on understanding the dynamics of actin filaments, which are crucial for cell movement and other essential processes in eukaryotic cells. The lab combines biochemical and biophysical techniques to explore how actin networks are built, remodeled, and recycled, and how these processes are regulated by various proteins. This research not only sheds light on fundamental cellular functions but also has implications for understanding diseases related to cell motility.
actin dynamicscell motilitybiomechanicsprotein regulationmolecular modelingRNA helicasecellular assemblyprotein recycling
Research Aims
5AIM 01Investigate the assembly dynamics of actin filament networks.
AIM 02Understand how regulatory proteins influence actin network mechanics.
AIM 03Assess the role of nucleotide binding in the Arp2/3 complex activity.
AIM 04Analyze the recycling processes of actin and associated proteins.
AIM 05Explore kinetic properties of RNA helicases involved in mRNA export.
Skills the Lab Values
biophysical analysesprotein purificationmicroscopykinetic assaysactin polymerization assayscell culture techniquesfluorescence spectroscopybiochemical assaysdata modeling using Python
Output against the department
Publications198top 42% of dept.167th of 402
this lab
most publishedleast published
Citations8.2kbottom 44% of dept.225th of 402
this lab
most citedleast cited
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