Thomas Jefferson University · BiochemistryNon-Coding RNA and Lung Injury Lab
Yohei Kirino · Philadelphia, Pennsylvania
Research Focus
Dr. Yohei Kirino's lab at Thomas Jefferson University focuses on understanding the role of small non-coding RNAs in acute lung injury (ALI), a serious respiratory condition. The lab aims to uncover how specific types of RNA derived from tRNA and rRNA contribute to the inflammatory response in ALI, which is associated with high morbidity and mortality. Using a novel sequencing technique, the lab's research may lead to new insights into potential biomarkers and therapeutic targets for treating this condition.
acute lung injurynon-coding RNAstRNA-derived RNAsinflammationRNA sequencingcytokinescell migrationTLR stimulationextracellular vesiclesimmune response
Research Aims
3AIM 01Characterize dysregulated tRNA halves and rRNA fragments in acute lung injury models.
AIM 02Investigate the proinflammatory effects of tRNA-derived RNAs through TLR stimulation.
AIM 03Determine the role of tRNA halves and rRFs in immune cell migration and infiltration in ALI.
Skills the Lab Values
RNA sequencingcell culturemouse modelsextraction of RNAendotoxin stimulationflow cytometrycytokine assaysbiological sample processingdata analysis with bioinformatics toolsmolecular cloning
Output against the department
Publications194top 44% of dept.176th of 402
this lab
most publishedleast published
Citations5.2kbottom 31% of dept.279th of 402
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.