Thomas Jefferson University · BiologyTriple Negative Breast Cancer Research Lab
Jun He · Philadelphia, Pennsylvania
Research Focus
Dr. Jun He's lab at Thomas Jefferson University focuses on understanding the mechanisms behind triple negative breast cancer (TNBC) and its resistance to treatments like chemotherapy and radiation. The lab investigates the role of a specific microRNA, miR-152, and how its suppression leads to the upregulation of pathways that promote tumor growth and resistance to therapy. The ultimate goal of this research is to identify new therapeutic targets to improve treatment outcomes for patients with TNBC.
breast cancertriple negative breast cancermiR-152chemotherapy resistanceradiation resistancemetabolic reprogrammingPKM2SLC7A5therapeutic targetstumor angiogenesis
Research Aims
3AIM 01Investigate the role of miR-152 suppression in TNBC cells and its effects on doxorubicin and radiation-induced resistance.
AIM 02Determine the function of the miR-152/SLC7A5/PTBP1 pathway in mediating metabolic reprogramming and therapeutic resistance.
AIM 03Assess the impact of miR-152 suppression on tumor angiogenesis and its correlation with therapeutic responses.
Skills the Lab Values
cell cultureRNA extractionPCRWestern blotgene expression analysisanimal modelsdrug treatment assaysflow cytometrytumor xenograftingbiochemical assays
Output against the department
Publications389top 12% of dept.122nd of 1,033
this lab
most publishedleast published
Citations21ktop 19% of dept.195th of 1,033
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.